Further, untargeted metabolomic analysis and pharmacological blocking assays revealed that the Bay117082-induced increase in sperm motility was attributable to fatty acid β-oxidation (FAO) enhancement. Nevertheless, Bay117082 treatment did not affect the motility of IKBA-knockout sperm. ![]() On the contrary, lipopolysaccharide-stimulated IKBA phosphorylation significantly decreased sperm motility. The repression of IKBA phosphorylation by its inhibitor Bay117082 markedly enhanced sperm motility. IKBA was highly expressed in human sperm. Herein we investigated the function of IKBA in mature sperm in which transcriptional and translational events do not occur. However, whether the upstream cascade of the canonical NF-κB signaling pathway has physiological roles independent of IKBA-mediated transcriptional activation remains unclear. ![]() ![]() NF-κB inhibitor alpha (IKBA) is an NF-κB inhibitory mediator in the cytoplasm that modulates the nuclear translocation and DNA binding activities of NF-κB proteins. The nuclear factor-κB (NF-κB) signaling pathway regulates specific immunological responses and controls a wide range of physiological processes.
0 Comments
Leave a Reply. |